Structure of PDB 1ey3 Chain D

Receptor sequence
>1ey3D (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
FQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAV
GAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIA
AVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRA
VGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANN
SKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEK
RKANFKDH
3D structure
PDB1ey3 Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion.
ChainD
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267
Catalytic site (residue number reindexed from 1) A66 M71 S81 L85 G109 E112 P131 E132 T137 P139 G140 K225 F235
Enzyme Commision number 4.2.1.17: enoyl-CoA hydratase.
5.3.3.8: Delta(3)-Delta(2)-enoyl-CoA isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DAK D K56 L58 A60 A96 G97 A98 D99 I100 K101 L117 W120 P163 L167 G172 K24 L26 A28 A64 G65 A66 D67 I68 K69 L85 W88 P131 L135 G140
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:1ey3, PDBe:1ey3, PDBj:1ey3
PDBsum1ey3
PubMed11851409
UniProtP14604|ECHM_RAT Enoyl-CoA hydratase, mitochondrial (Gene Name=Echs1)

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