Structure of PDB 1e6v Chain D

Receptor sequence
>1e6vD (length=545) Species: 2320 (Methanopyrus kandleri) [Search protein sequence]
LFMKALKEKFEESPEEKYTKFYIFGGWKQSERKKEFKEWADKIVEERGVP
HYNPDIGVPLGQRKLMSYQVSGTDVFVEGDDLTFVNNAAMQQMWDDIRRT
VIVGMDTAHRVLERRLGKEVTPETINEYMETLNHALPGGAVVQEHMVEIH
PGLTWDCYAKIITGDLELADEIDDKFLIDIEKLFPEEQAEQLIKAIGNRT
YQVCRMPTIVGHVCDGATMYRWAAMQIAMSFICAYKIAAGEAAVSDFAFA
SKHAEVINMGEMLPARRARGENEPGGVPFGVLADCVQTMRKYPDDPAKVA
LEVIAAGAMLYDQIWLGSYMSGGVGFTQYATAVYPDNILDDYVYYGLEYV
EDKYGIAEAEPSMDVVKDVATEVTLYGLEQYERYPAAMETHFGGSQRAAV
CAAAAGCSTAFATGHAQAGLNGWYLSQILHKEGQGRLGFYGYALQDQCGA
ANSLSVRSDEGLPLELRGPNYPNYAMNVGHLGEYAGIVQAAHAARGDAFC
VHPVIKVAFADENLVFDFTEPRKEFAKGALREFEPAGERDLIVPA
3D structure
PDB1e6v Comparison of Three Methyl-Coenzyme M Reductases from Phylogenetically Distant Organisms: Unusual Amino Acid Modification, Conservation and Adaptation
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q150 Y336 G448 N484
Catalytic site (residue number reindexed from 1) Q143 Y329 G441 N477
Enzyme Commision number 2.8.4.1: coenzyme-B sulfoethylthiotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F43 D V331 G332 F333 T334 Q335 Y336 V324 G325 F326 T327 Q328 Y329
BS02 TP7 D K259 H260 K252 H253
BS03 COM D Y336 F446 Y447 Y329 F439 Y440
BS04 F43 D A147 V148 V149 Q150 M153 M236 A246 A140 V141 V142 Q143 M146 M229 A239
BS05 TP7 D R273 M327 F333 F446 M483 N484 R266 M320 F326 F439 M476 N477
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0050524 coenzyme-B sulfoethylthiotransferase activity
Biological Process
GO:0015948 methanogenesis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1e6v, PDBe:1e6v, PDBj:1e6v
PDBsum1e6v
PubMed11023796
UniProtQ49605|MCRA_METKA Methyl-coenzyme M reductase I subunit alpha (Gene Name=mcrA)

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