Structure of PDB 1dxq Chain D

Receptor sequence

>1dxqD (length=273) Species: 10090 (Mus musculus) [Search protein sequence]

AARRALIVLAHSEKTSFNYAMKEAAVEALKKRGWEVLESDLYAMNFNPII
SRNDITGELKDSKNFQYPSESSLAYKEGRLSPDIVAEHKKLEAADLVIFQ
FPLQWFGVPAILKGWFERVLVAGFAYTYAAMYDNGPFQNKKTLLSITTGG
SGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDAR
MQILEGWKKRLETVWEETPLYFAPSSLFDLNFQAGFLLMKEVQEEQKKNK
FGLSVGHHLGKSIPADNQIKARK

3D structure

PDB

1dxq Structures of Recombinant Mouse and Human Nad(P)H:Quinone Oxidoreductases:Species Comparison and Structural Changes with Substrate Binding and Release

Chain

Resolution

2.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	G149 Y155 H161
Catalytic site (residue number reindexed from 1)	G149 Y155 H161
Enzyme Commision number	1.6.5.2: NAD(P)H dehydrogenase (quinone).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	D	Q66 P68 E117	Q66 P68 E117
BS02	FAD	D	H11 S16 F17 N18 A20 P102 L103 Q104 W105 F106 T147 T148 G149 G150 Y155 R200	H11 S16 F17 N18 A20 P102 L103 Q104 W105 F106 T147 T148 G149 G150 Y155 R200

Gene Ontology

	Molecular Function
GO:0003955	NAD(P)H dehydrogenase (quinone) activity
GO:0004784	superoxide dismutase activity
GO:0005515	protein binding
GO:0008753	NADPH dehydrogenase (quinone) activity
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0050136	NADH:ubiquinone reductase (non-electrogenic) activity

	Biological Process
GO:0000209	protein polyubiquitination
GO:0002931	response to ischemia
GO:0006116	NADH oxidation
GO:0006743	ubiquinone metabolic process
GO:0006801	superoxide metabolic process
GO:0006979	response to oxidative stress
GO:0007584	response to nutrient
GO:0009410	response to xenobiotic stimulus
GO:0009725	response to hormone
GO:0009743	response to carbohydrate
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0019430	removal of superoxide radicals
GO:0030163	protein catabolic process
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0033574	response to testosterone
GO:0034599	cellular response to oxidative stress
GO:0042177	negative regulation of protein catabolic process
GO:0042360	vitamin E metabolic process
GO:0042373	vitamin K metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043279	response to alkaloid
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0045454	cell redox homeostasis
GO:0045471	response to ethanol
GO:0051602	response to electrical stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0070995	NADPH oxidation
GO:0071248	cellular response to metal ion
GO:0110076	negative regulation of ferroptosis
GO:1904772	response to tetrachloromethane
GO:1904844	response to L-glutamine
GO:1904880	response to hydrogen sulfide
GO:1905395	response to flavonoid

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0043025	neuronal cell body

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1dxq, PDBe:1dxq, PDBj:1dxq
PDBsum	1dxq
PubMed	10706635
UniProt	Q64669\|NQO1_MOUSE NAD(P)H dehydrogenase [quinone] 1 (Gene Name=Nqo1)

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