Structure of PDB 1de5 Chain D

Receptor sequence
>1de5D (length=416) Species: 562 (Escherichia coli) [Search protein sequence]
TQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFENPE
GSLTGGIQATGNYPGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESD
TPVSRDQIKPEHFKNWVEWAKANQLGLDFNPSCFSHPLSADGFTLSHADD
SIRQFWIDHCKASRRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQ
RLLAALDEVISEKLNPAHHIDAVESKLFGIGAESYTVGSNEFYMGYATSR
QTALCLDAGHFHPTEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVLLD
DETQAIASEIVRHDLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRA
LLEPTAELRKLEAPGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSE
WLESVRAYEKEILSRR
3D structure
PDB1de5 The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W193 E234 K236 D267 H270 H294 D302 D304 D334
Catalytic site (residue number reindexed from 1) W183 E224 K226 D257 H260 H284 D292 D294 D324
Enzyme Commision number 5.3.1.14: L-rhamnose isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RNT D W48 I67 H103 W193 E234 K236 H270 H294 D334 W38 I57 H93 W183 E224 K226 H260 H284 D324
BS02 ZN D E234 D267 H294 D334 E224 D257 H284 D324
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008740 L-rhamnose isomerase activity
GO:0016853 isomerase activity
GO:0030145 manganese ion binding
GO:0033296 rhamnose binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0019299 rhamnose metabolic process
GO:0019301 rhamnose catabolic process
GO:0019324 L-lyxose metabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1de5, PDBe:1de5, PDBj:1de5
PDBsum1de5
PubMed10891278
UniProtP32170|RHAA_ECOLI L-rhamnose isomerase (Gene Name=rhaA)

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