Structure of PDB 1cli Chain D

Receptor sequence
>1cliD (length=325) Species: 562 (Escherichia coli) [Search protein sequence]
ALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTK
LRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTAS
AVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEII
DGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLAD
HLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVID
ESSWQWPEVFNWLQTAGNVEHHEMYRTFNCGVGMIIALPAPEVDKALALL
NANGENAWKIGIIKASDSEQRVVIE
3D structure
PDB1cli X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 D T3069 N3192 G3193 Y3194 S3195 T49 N172 G173 Y174 S175
Gene Ontology
Molecular Function
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0046084 adenine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1cli, PDBe:1cli, PDBj:1cli
PDBsum1cli
PubMed10508786
UniProtP08178|PUR5_ECOLI Phosphoribosylformylglycinamidine cyclo-ligase (Gene Name=purM)

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