Structure of PDB 1atn Chain D

Receptor sequence
>1atnD (length=258) Species: 9913 (Bos taurus) [Search protein sequence]
LKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEVRDSHLVAVGK
LLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYDDG
CCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDVYL
DVQQKWHLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADT
TATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYGLSNEMALAISDH
YPVEVTLT
3D structure
PDB1atn Atomic structure of the actin:DNase I complex.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.1: deoxyribonuclease I.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CA D D201 T203 T205 T207 D199 T201 T203 T205
BS02 CA D D99 C101 D107 F109 E112 D99 C101 D105 F107 E110
BS03 CA D D172 D198 N208 D170 D196 N206
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0003824 catalytic activity
GO:0004519 endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0004536 DNA nuclease activity
GO:0005515 protein binding
Biological Process
GO:0002283 neutrophil activation involved in immune response
GO:0002673 regulation of acute inflammatory response
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
GO:0070948 regulation of neutrophil mediated cytotoxicity
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0031410 cytoplasmic vesicle
GO:0042588 zymogen granule

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1atn, PDBe:1atn, PDBj:1atn
PDBsum1atn
PubMed2395459
UniProtP00639|DNAS1_BOVIN Deoxyribonuclease-1 (Gene Name=DNASE1)

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