/var/www/html/BioLiP/script/receptor1 /var/www/html/BioLiP/output/7yl0D.pdb.gz -
ATOM 1 N LYS R 1 198.606 141.146 139.565 1.00186.14 N
ATOM 2 CA LYS R 1 197.530 141.726 138.774 1.00186.14 C
ATOM 3 C LYS R 1 197.230 143.154 139.210 1.00186.14 C
ATOM 4 O LYS R 1 197.827 144.087 138.702 1.00186.14 O
ATOM 5 CB LYS R 1 196.271 140.868 138.862 1.00186.14 C
ATOM 6 CG LYS R 1 196.420 139.508 138.202 1.00186.14 C
ATOM 7 CD LYS R 1 195.089 138.785 138.098 1.00186.14 C
ATOM 8 CE LYS R 1 195.230 137.505 137.294 1.00186.14 C
ATOM 9 NZ LYS R 1 193.944 136.763 137.190 1.00186.14 N
ATOM 10 N CYS R 2 196.315 143.300 140.156 1.00190.10 N
ATOM 11 CA CYS R 2 195.907 144.624 140.592 1.00190.10 C
ATOM 12 C CYS R 2 196.719 145.076 141.819 1.00190.10 C
ATOM 13 O CYS R 2 196.162 145.214 142.906 1.00190.10 O
ATOM 14 CB CYS R 2 194.380 144.592 140.833 1.00190.10 C
ATOM 15 SG CYS R 2 193.443 143.547 139.640 1.00190.10 S
ATOM 16 N ASN R 3 198.027 145.316 141.652 1.00192.23 N
ATOM 17 CA ASN R 3 198.877 145.696 142.755 1.00192.23 C
ATOM 18 C ASN R 3 198.457 147.015 143.335 1.00192.23 C
ATOM 19 O ASN R 3 198.403 147.113 144.532 1.00192.23 O
ATOM 20 CB ASN R 3 200.334 145.796 142.299 1.00192.23 C
ATOM 21 CG ASN R 3 200.953 144.443 142.002 1.00192.23 C
ATOM 22 OD1 ASN R 3 200.508 143.409 142.500 1.00192.23 O
ATOM 23 ND2 ASN R 3 201.992 144.446 141.179 1.00192.23 N
ATOM 24 N THR R 4 198.093 148.006 142.517 1.00191.05 N
ATOM 25 CA THR R 4 197.827 149.353 143.030 1.00191.05 C
ATOM 26 C THR R 4 196.418 149.750 143.492 1.00191.05 C
ATOM 27 O THR R 4 196.239 150.002 144.685 1.00191.05 O
ATOM 28 CB THR R 4 198.316 150.417 142.032 1.00 30.00 C
ATOM 29 OG1 THR R 4 199.733 150.282 141.841 1.00 30.00 O
ATOM 30 CG2 THR R 4 198.009 151.817 142.543 1.00 30.00 C
ATOM 31 N ALA R 5 195.416 149.780 142.611 1.00184.18 N
ATOM 32 CA ALA R 5 194.099 150.265 143.073 1.00184.18 C
ATOM 33 C ALA R 5 192.805 149.887 142.371 1.00184.18 C
ATOM 34 O ALA R 5 192.820 149.582 141.179 1.00184.18 O
ATOM 35 CB ALA R 5 194.146 151.783 143.207 1.00184.18 C
ATOM 36 N THR R 6 191.702 149.855 143.117 1.00176.83 N
ATOM 37 CA THR R 6 190.357 149.676 142.547 1.00176.83 C
ATOM 38 C THR R 6 190.093 148.543 141.551 1.00176.83 C
ATOM 39 O THR R 6 189.515 148.787 140.492 1.00176.83 O
ATOM 40 CB THR R 6 189.855 150.995 141.920 1.00176.83 C
ATOM 41 OG1 THR R 6 190.136 152.087 142.804 1.00176.83 O
ATOM 42 CG2 THR R 6 188.354 150.929 141.664 1.00176.83 C
ATOM 43 N CYS R 7 190.484 147.333 141.898 1.00173.53 N
ATOM 44 CA CYS R 7 190.264 146.222 141.005 1.00173.53 C
ATOM 45 C CYS R 7 189.137 145.372 141.524 1.00173.53 C
ATOM 46 O CYS R 7 189.208 144.865 142.644 1.00173.53 O
ATOM 47 CB CYS R 7 191.520 145.392 140.937 1.00173.53 C
ATOM 48 SG CYS R 7 191.436 143.952 139.861 1.00173.53 S
ATOM 49 N ALA R 8 188.090 145.196 140.729 1.00151.59 N
ATOM 50 CA ALA R 8 187.045 144.300 141.192 1.00151.59 C
ATOM 51 C ALA R 8 186.874 143.139 140.234 1.00151.59 C
ATOM 52 O ALA R 8 187.042 143.315 139.028 1.00151.59 O
ATOM 53 CB ALA R 8 185.743 145.053 141.328 1.00151.59 C
ATOM 54 N THR R 9 186.542 141.966 140.756 1.00140.87 N
ATOM 55 CA THR R 9 186.386 140.781 139.923 1.00140.87 C
ATOM 56 C THR R 9 185.286 139.878 140.393 1.00140.87 C
ATOM 57 O THR R 9 185.282 139.459 141.543 1.00140.87 O
ATOM 58 CB THR R 9 187.660 139.922 139.944 1.00140.87 C
ATOM 59 OG1 THR R 9 188.758 140.687 139.426 1.00140.87 O
ATOM 60 CG2 THR R 9 187.487 138.665 139.104 1.00140.87 C
ATOM 61 N GLN R 10 184.351 139.559 139.515 1.00127.98 N
ATOM 62 CA GLN R 10 183.335 138.591 139.879 1.00127.98 C
ATOM 63 C GLN R 10 183.666 137.367 139.060 1.00127.98 C
ATOM 64 O GLN R 10 183.786 137.445 137.839 1.00127.98 O
ATOM 65 CB GLN R 10 181.934 139.096 139.541 1.00127.98 C
ATOM 66 CG GLN R 10 180.828 138.091 139.803 1.00127.98 C
ATOM 67 CD GLN R 10 179.460 138.734 139.811 1.00127.98 C
ATOM 68 OE1 GLN R 10 179.337 139.953 139.924 1.00127.98 O
ATOM 69 NE2 GLN R 10 178.419 137.918 139.697 1.00127.98 N
ATOM 70 N ARG R 11 183.823 136.231 139.724 1.00126.76 N
ATOM 71 CA ARG R 11 184.187 135.002 139.043 1.00126.76 C
ATOM 72 C ARG R 11 183.021 134.041 139.164 1.00126.76 C
ATOM 73 O ARG R 11 182.676 133.650 140.270 1.00126.76 O
ATOM 74 CB ARG R 11 185.421 134.451 139.737 1.00126.76 C
ATOM 75 CG ARG R 11 185.989 133.155 139.195 1.00126.76 C
ATOM 76 CD ARG R 11 187.206 132.776 140.023 1.00126.76 C
ATOM 77 NE ARG R 11 187.741 131.460 139.693 1.00126.76 N
ATOM 78 CZ ARG R 11 188.791 130.915 140.300 1.00126.76 C
ATOM 79 NH1 ARG R 11 189.414 131.577 141.265 1.00126.76 N
ATOM 80 NH2 ARG R 11 189.219 129.712 139.945 1.00126.76 N
ATOM 81 N LEU R 12 182.374 133.735 138.054 1.00115.44 N
ATOM 82 CA LEU R 12 181.265 132.817 138.130 1.00115.44 C
ATOM 83 C LEU R 12 181.452 131.621 137.222 1.00115.44 C
ATOM 84 O LEU R 12 181.569 131.756 136.003 1.00115.44 O
ATOM 85 CB LEU R 12 179.955 133.533 137.790 1.00115.44 C
ATOM 86 CG LEU R 12 178.662 132.735 137.969 1.00115.44 C
ATOM 87 CD1 LEU R 12 177.446 133.634 137.795 1.00115.44 C
ATOM 88 CD2 LEU R 12 178.605 131.559 137.006 1.00115.44 C
ATOM 89 N ALA R 13 181.477 130.446 137.831 1.00114.35 N
ATOM 90 CA ALA R 13 181.540 129.203 137.073 1.00114.35 C
ATOM 91 C ALA R 13 180.278 128.412 137.357 1.00114.35 C
ATOM 92 O ALA R 13 180.093 127.913 138.472 1.00114.35 O
ATOM 93 CB ALA R 13 182.785 128.394 137.449 1.00114.35 C
ATOM 94 N ASN R 14 179.411 128.314 136.351 1.00113.22 N
ATOM 95 CA ASN R 14 178.157 127.596 136.511 1.00113.22 C
ATOM 96 C ASN R 14 178.109 126.376 135.626 1.00113.22 C
ATOM 97 O ASN R 14 178.319 126.476 134.428 1.00113.22 O
ATOM 98 CB ASN R 14 176.971 128.510 136.224 1.00113.22 C
ATOM 99 CG ASN R 14 175.637 127.857 136.524 1.00113.22 C
ATOM 100 OD1 ASN R 14 174.628 128.176 135.898 1.00113.22 O
ATOM 101 ND2 ASN R 14 175.624 126.944 137.481 1.00113.22 N
ATOM 102 N PHE R 15 177.852 125.222 136.206 1.00111.78 N
ATOM 103 CA PHE R 15 177.758 123.960 135.488 1.00111.78 C
ATOM 104 C PHE R 15 176.451 123.294 135.872 1.00111.78 C
ATOM 105 O PHE R 15 176.181 123.088 137.057 1.00111.78 O
ATOM 106 CB PHE R 15 178.936 123.034 135.817 1.00111.78 C
ATOM 107 CG PHE R 15 180.280 123.708 135.757 1.00111.78 C
ATOM 108 CD1 PHE R 15 180.735 124.477 136.815 1.00111.78 C
ATOM 109 CD2 PHE R 15 181.107 123.545 134.658 1.00111.78 C
ATOM 110 CE1 PHE R 15 181.972 125.089 136.768 1.00111.78 C
ATOM 111 CE2 PHE R 15 182.350 124.153 134.611 1.00111.78 C
ATOM 112 CZ PHE R 15 182.780 124.926 135.667 1.00111.78 C
ATOM 113 N LEU R 16 175.650 122.958 134.866 1.00 96.46 N
ATOM 114 CA LEU R 16 174.357 122.330 135.095 1.00 96.46 C
ATOM 115 C LEU R 16 174.307 121.052 134.274 1.00 96.46 C
ATOM 116 O LEU R 16 174.676 121.061 133.105 1.00 96.46 O
ATOM 117 CB LEU R 16 173.259 123.276 134.625 1.00 96.46 C
ATOM 118 CG LEU R 16 171.826 123.118 135.121 1.00 96.46 C
ATOM 119 CD1 LEU R 16 171.165 124.484 135.069 1.00 96.46 C
ATOM 120 CD2 LEU R 16 171.060 122.132 134.252 1.00 96.46 C
ATOM 121 N VAL R 17 173.860 119.955 134.876 1.00 93.92 N
ATOM 122 CA VAL R 17 173.769 118.684 134.173 1.00 93.92 C
ATOM 123 C VAL R 17 172.397 118.081 134.378 1.00 93.92 C
ATOM 124 O VAL R 17 172.159 117.443 135.384 1.00 93.92 O
ATOM 125 CB VAL R 17 174.780 117.682 134.737 1.00 93.92 C
ATOM 126 CG1 VAL R 17 174.767 116.385 133.939 1.00 93.92 C
ATOM 127 CG2 VAL R 17 176.179 118.270 134.785 1.00 93.92 C
ATOM 128 N HIS R 18 171.491 118.266 133.436 1.00 93.10 N
ATOM 129 CA HIS R 18 170.191 117.652 133.554 1.00 93.10 C
ATOM 130 C HIS R 18 170.246 116.419 132.721 1.00 93.10 C
ATOM 131 O HIS R 18 170.492 116.489 131.533 1.00 93.10 O
ATOM 132 CB HIS R 18 169.109 118.570 133.008 1.00 93.10 C
ATOM 133 CG HIS R 18 167.737 117.971 133.008 1.00 93.10 C
ATOM 134 ND1 HIS R 18 166.778 118.316 133.931 1.00 93.10 N
ATOM 135 CD2 HIS R 18 167.158 117.062 132.186 1.00 93.10 C
ATOM 136 CE1 HIS R 18 165.669 117.644 133.686 1.00 93.10 C
ATOM 137 NE2 HIS R 18 165.873 116.874 132.633 1.00 93.10 N
ATOM 138 N SER R 19 170.010 115.275 133.322 1.00 95.21 N
ATOM 139 CA SER R 19 170.005 114.049 132.572 1.00 95.21 C
ATOM 140 C SER R 19 168.808 113.238 132.934 1.00 95.21 C
ATOM 141 O SER R 19 168.559 113.007 134.101 1.00 95.21 O
ATOM 142 CB SER R 19 171.252 113.247 132.869 1.00 95.21 C
ATOM 143 OG SER R 19 171.167 111.960 132.287 1.00 95.21 O
ATOM 144 N SER R 20 168.053 112.796 131.948 1.00 97.57 N
ATOM 145 CA SER R 20 166.950 111.920 132.253 1.00 97.57 C
ATOM 146 C SER R 20 167.146 110.666 131.470 1.00 97.57 C
ATOM 147 O SER R 20 167.174 110.707 130.256 1.00 97.57 O
ATOM 148 CB SER R 20 165.632 112.558 131.853 1.00 97.57 C
ATOM 149 OG SER R 20 164.586 111.607 131.888 1.00 97.57 O
ATOM 150 N ASN R 21 167.309 109.529 132.124 1.00 97.79 N
ATOM 151 CA ASN R 21 167.394 108.269 131.411 1.00 97.79 C
ATOM 152 C ASN R 21 166.125 107.557 131.753 1.00 97.79 C
ATOM 153 O ASN R 21 165.976 107.086 132.867 1.00 97.79 O
ATOM 154 CB ASN R 21 168.595 107.460 131.860 1.00 97.79 C
ATOM 155 CG ASN R 21 169.908 108.157 131.581 1.00 97.79 C
ATOM 156 OD1 ASN R 21 170.919 107.860 132.213 1.00 97.79 O
ATOM 157 ND2 ASN R 21 169.905 109.084 130.633 1.00 97.79 N
ATOM 158 N ASN R 22 165.191 107.507 130.825 1.00 96.40 N
ATOM 159 CA ASN R 22 163.905 106.908 131.106 1.00 96.40 C
ATOM 160 C ASN R 22 163.830 105.517 130.533 1.00 96.40 C
ATOM 161 O ASN R 22 163.461 105.347 129.381 1.00 96.40 O
ATOM 162 CB ASN R 22 162.819 107.801 130.524 1.00 96.40 C
ATOM 163 CG ASN R 22 161.473 107.131 130.441 1.00 96.40 C
ATOM 164 OD1 ASN R 22 160.765 107.282 129.455 1.00 96.40 O
ATOM 165 ND2 ASN R 22 161.123 106.377 131.453 1.00 96.40 N
ATOM 166 N PHE R 23 164.198 104.503 131.302 1.00100.58 N
ATOM 167 CA PHE R 23 164.020 103.161 130.767 1.00100.58 C
ATOM 168 C PHE R 23 162.635 102.691 131.120 1.00100.58 C
ATOM 169 O PHE R 23 162.499 101.673 131.783 1.00100.58 O
ATOM 170 CB PHE R 23 164.987 102.174 131.410 1.00100.58 C
ATOM 171 CG PHE R 23 166.432 102.445 131.138 1.00100.58 C
ATOM 172 CD1 PHE R 23 167.099 103.467 131.790 1.00100.58 C
ATOM 173 CD2 PHE R 23 167.141 101.641 130.270 1.00100.58 C
ATOM 174 CE1 PHE R 23 168.433 103.706 131.550 1.00100.58 C
ATOM 175 CE2 PHE R 23 168.481 101.869 130.028 1.00100.58 C
ATOM 176 CZ PHE R 23 169.129 102.906 130.668 1.00100.58 C
ATOM 177 N GLY R 24 161.600 103.380 130.681 1.00101.55 N
ATOM 178 CA GLY R 24 160.268 103.008 131.110 1.00101.55 C
ATOM 179 C GLY R 24 159.226 103.976 130.623 1.00101.55 C
ATOM 180 O GLY R 24 159.475 104.732 129.696 1.00101.55 O
ATOM 181 N ALA R 25 158.062 103.982 131.251 1.00 99.93 N
ATOM 182 CA ALA R 25 156.982 104.828 130.773 1.00 99.93 C
ATOM 183 C ALA R 25 156.763 106.073 131.587 1.00 99.93 C
ATOM 184 O ALA R 25 156.572 106.000 132.784 1.00 99.93 O
ATOM 185 CB ALA R 25 155.700 104.031 130.718 1.00 99.93 C
ATOM 186 N ILE R 26 156.791 107.229 130.935 1.00 94.15 N
ATOM 187 CA ILE R 26 156.507 108.487 131.601 1.00 94.15 C
ATOM 188 C ILE R 26 155.282 108.988 130.895 1.00 94.15 C
ATOM 189 O ILE R 26 155.256 109.027 129.680 1.00 94.15 O
ATOM 190 CB ILE R 26 157.586 109.545 131.342 1.00 94.15 C
ATOM 191 CG1 ILE R 26 158.945 109.095 131.849 1.00 94.15 C
ATOM 192 CG2 ILE R 26 157.211 110.876 131.976 1.00 94.15 C
ATOM 193 CD1 ILE R 26 159.987 110.186 131.776 1.00 94.15 C
ATOM 194 N LEU R 27 154.252 109.363 131.625 1.00 96.67 N
ATOM 195 CA LEU R 27 153.087 109.932 130.993 1.00 96.67 C
ATOM 196 C LEU R 27 152.854 111.261 131.646 1.00 96.67 C
ATOM 197 O LEU R 27 152.877 111.363 132.861 1.00 96.67 O
ATOM 198 CB LEU R 27 151.888 109.014 131.195 1.00 96.67 C
ATOM 199 CG LEU R 27 150.532 109.286 130.538 1.00 96.67 C
ATOM 200 CD1 LEU R 27 149.784 107.975 130.354 1.00 96.67 C
ATOM 201 CD2 LEU R 27 149.677 110.280 131.308 1.00 96.67 C
ATOM 202 N SER R 28 152.589 112.285 130.855 1.00 94.85 N
ATOM 203 CA SER R 28 152.377 113.609 131.401 1.00 94.85 C
ATOM 204 C SER R 28 151.303 114.371 130.680 1.00 94.85 C
ATOM 205 O SER R 28 151.233 114.334 129.467 1.00 94.85 O
ATOM 206 CB SER R 28 153.662 114.412 131.344 1.00 94.85 C
ATOM 207 OG SER R 28 153.421 115.762 131.688 1.00 94.85 O
ATOM 208 N SER R 29 150.464 115.081 131.412 1.00 93.36 N
ATOM 209 CA SER R 29 149.438 115.889 130.784 1.00 93.36 C
ATOM 210 C SER R 29 149.409 117.255 131.406 1.00 93.36 C
ATOM 211 O SER R 29 149.291 117.373 132.609 1.00 93.36 O
ATOM 212 CB SER R 29 148.075 115.241 130.943 1.00 93.36 C
ATOM 213 OG SER R 29 147.053 116.124 130.523 1.00 93.36 O
ATOM 214 N THR R 30 149.509 118.298 130.600 1.00 87.13 N
ATOM 215 CA THR R 30 149.406 119.636 131.140 1.00 87.13 C
ATOM 216 C THR R 30 148.210 120.268 130.485 1.00 87.13 C
ATOM 217 O THR R 30 148.201 120.437 129.283 1.00 87.13 O
ATOM 218 CB THR R 30 150.650 120.458 130.810 1.00 87.13 C
ATOM 219 OG1 THR R 30 151.820 119.718 131.179 1.00 87.13 O
ATOM 220 CG2 THR R 30 150.634 121.776 131.559 1.00 87.13 C
ATOM 221 N ASN R 31 147.180 120.600 131.243 1.00 82.15 N
ATOM 222 CA ASN R 31 145.985 121.156 130.651 1.00 82.15 C
ATOM 223 C ASN R 31 145.761 122.545 131.194 1.00 82.15 C
ATOM 224 O ASN R 31 145.009 122.721 132.134 1.00 82.15 O
ATOM 225 CB ASN R 31 144.756 120.309 130.953 1.00 82.15 C
ATOM 226 CG ASN R 31 144.831 118.916 130.370 1.00 82.15 C
ATOM 227 OD1 ASN R 31 144.072 118.035 130.768 1.00 82.15 O
ATOM 228 ND2 ASN R 31 145.732 118.705 129.424 1.00 82.15 N
ATOM 229 N VAL R 32 146.392 123.543 130.599 1.00 77.91 N
ATOM 230 CA VAL R 32 146.261 124.887 131.126 1.00 77.91 C
ATOM 231 C VAL R 32 145.170 125.668 130.429 1.00 77.91 C
ATOM 232 O VAL R 32 145.272 125.954 129.252 1.00 77.91 O
ATOM 233 CB VAL R 32 147.526 125.682 130.883 1.00 77.91 C
ATOM 234 CG1 VAL R 32 147.292 127.130 131.267 1.00 77.91 C
ATOM 235 CG2 VAL R 32 148.694 125.066 131.633 1.00 77.91 C
ATOM 236 N GLY R 33 144.131 126.040 131.172 1.00 75.92 N
ATOM 237 CA GLY R 33 143.043 126.818 130.601 1.00 75.92 C
ATOM 238 C GLY R 33 142.085 125.960 129.811 1.00 75.92 C
ATOM 239 O GLY R 33 141.052 126.442 129.345 1.00 75.92 O
ATOM 240 N SER R 34 142.415 124.684 129.658 1.00 76.59 N
ATOM 241 CA SER R 34 141.574 123.788 128.916 1.00 76.59 C
ATOM 242 C SER R 34 140.333 123.501 129.676 1.00 76.59 C
ATOM 243 O SER R 34 140.298 123.709 130.839 1.00 76.59 O
ATOM 244 CB SER R 34 142.319 122.496 128.677 1.00 76.59 C
ATOM 245 OG SER R 34 141.487 121.543 128.047 1.00 76.59 O
ATOM 246 N ASN R 35 139.273 123.076 129.033 1.00 79.18 N
ATOM 247 CA ASN R 35 138.104 122.680 129.775 1.00 79.18 C
ATOM 248 C ASN R 35 137.513 121.493 129.090 1.00 79.18 C
ATOM 249 O ASN R 35 137.664 121.346 127.905 1.00 79.18 O
ATOM 250 CB ASN R 35 137.083 123.800 129.822 1.00 79.18 C
ATOM 251 CG ASN R 35 137.621 125.059 130.456 1.00 79.18 C
ATOM 252 OD1 ASN R 35 137.839 126.064 129.793 1.00 79.18 O
ATOM 253 ND2 ASN R 35 137.865 125.001 131.744 1.00 79.18 N
ATOM 254 N THR R 36 136.843 120.629 129.816 1.00 87.70 N
ATOM 255 CA THR R 36 136.173 119.520 129.183 1.00 87.70 C
ATOM 256 C THR R 36 134.721 119.615 129.531 1.00 87.70 C
ATOM 257 O THR R 36 134.379 119.713 130.695 1.00 87.70 O
ATOM 258 CB THR R 36 136.716 118.188 129.683 1.00 87.70 C
ATOM 259 OG1 THR R 36 138.141 118.175 129.550 1.00 87.70 O
ATOM 260 CG2 THR R 36 136.129 117.039 128.892 1.00 87.70 C
ATOM 261 N TYR R 37 133.678 119.798 128.951 1.00 20.00 N
ATOM 262 CA TYR R 37 132.209 119.820 128.956 1.00 20.00 C
ATOM 263 C TYR R 37 131.686 118.450 128.608 1.00 20.00 C
ATOM 264 O TYR R 37 132.327 117.723 127.880 1.00 20.00 O
ATOM 265 CB TYR R 37 131.710 120.836 127.929 1.00 20.00 C
ATOM 266 CG TYR R 37 132.105 122.223 128.360 1.00 20.00 C
ATOM 267 CD1 TYR R 37 133.394 122.672 128.141 1.00 20.00 C
ATOM 268 CD2 TYR R 37 131.176 123.047 128.969 1.00 20.00 C
ATOM 269 CE1 TYR R 37 133.757 123.946 128.537 1.00 20.00 C
ATOM 270 CE2 TYR R 37 131.536 124.317 129.369 1.00 20.00 C
ATOM 271 OH TYR R 37 133.185 126.026 129.542 1.00 20.00 O
ATOM 272 CZ TYR R 37 132.829 124.772 129.152 1.00 20.00 C
ATOM 273 NXT TYR R 37 130.504 118.034 129.104 1.00 20.00 N
TER