Structure of PDB 6hiy Chain Cv

Receptor sequence
>6hiyCv (length=1059) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
LKTLDVREYRPLAMPIEFRFYQRYANHPNRQSGIQFLTHYNTHQRFRVNK
DYIDYMHWGKEQGQARLPHRHQRVAFDFNDQLHPTRIGYAWFASQDPTFG
HHPDLSSSFDPNYRVFSHPEHWNKMFTKRRPGEGDIDLSVLPSRSLLGPL
MAHSDTKGIPYFKVDNRGHSNGRVPGVNAPFFGEFDQKMMQAMSRPLNAN
RTITGNDGRFSKTIMINEPQCNQALSAKTASELSKEIDKATNAVYSKLSV
LEAAQSGLTDYFCGGLNFEIVGFELHMAAMLRERAAAILERSGACAMLLE
KADEREVNKLLRDASRYEDRVDDALRQHASLIWRVYTAPRPLMTLTNGKC
RGTGCGLSLFAKYCALKDSSEFIFDGPNVGITPYGGMTRLLARPETSLKY
PGLAEFVVLTGASLFAGDALRLGWTDLFTTIPDMTYHIKEWFDTTEHMHN
DAVAWQLGHLLETCFKMKESHSSAMERAAITPTRARWVEDAFADQPSVND
IMRTLTEIEQLPFQSTHNTSDESHITPYTLGSVAAGVQRLGEHRLRYTLS
PWDITPPEDSVVLKHTSEMFRAYVLERRGATDVVTHRDAERAAAWSQQRQ
REYDAYCSLKEAPHPRHVYARLEGCEGKIVSFEFVFEISCTTTISRLKSR
ILDALGMPRDRNIDLGWYLPTLDTCPIHSDEELMQVLHTDPGIEDPKEKL
RYPPIYFIVKRCTLYFSEWAYAVKHQLLLQSPFALRAAFGLLQEVRGDGA
AENVMPLAETLGTEFKYFTRLMRRPDFYRVGVHTDKSVEKWEEIKEERRH
NIHHTHRPTRPLPDFEEVFERDVEIDGHRFVLRPRWNPRTLQDVDDSDIL
RLRAPLTYDMDSTAALHVPTHCGKASRLAGMLQDAGGVQVLDGLGEVDDK
GEPKVPPLQSNASVPTNVSFYEMARHPWEDRASSWRRDGFTEGSLEYFES
QYRSAERAVYDEEGRGVRNYWPSRDAVEGIAQEEENDAQLLQERLFNTLE
TAGTSVEPWARNLRLNATTGKFGYKTEIATQEEKIYDDEYYRWFIQPGRH
PNPSGLTLN
3D structure
PDB6hiy Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
ChainCv
Resolution3.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Cv L26 T28 L29 D30 V31 R32 E33 Y34 R35 P36 A38 M39 P40 F43 R44 Y46 Q47 R48 Y49 H52 R55 I59 R72 R240 P241 L1 T3 L4 D5 V6 R7 E8 Y9 R10 P11 A13 M14 P15 F18 R19 Y21 Q22 R23 Y24 H27 R30 I34 R47 R195 P196
BS02 peptide Cv D554 A557 Q559 E571 H581 D490 A493 Q495 E507 H517
Gene Ontology
Molecular Function
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hiy, PDBe:6hiy, PDBj:6hiy
PDBsum6hiy
PubMed30213880
UniProtQ383R4

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