Structure of PDB 6hiy Chain Ca

Receptor sequence

>6hiyCa (length=592) Species: 5702 (Trypanosoma brucei brucei)

RYPFNKRGPREHKSWKHHVLTEPPKPLQWRDPKVWTRDLSVMKSFDAPQW
DLWQSRPRSEDMDEALQPFMDMPKSLKDRRYDIPWWANPFGAWYLQNILS
LELLKLKSKTNAEKIATYRSYMRSLASGKDNTMSDDDVIRNIIKERWKTL
EFGDRNAGYPCTFGDYIQFLNEWFKSLDEEGMQRLREHFDRRIRPLLAVM
SPVDILWLEALTQNSPHNKEQLQRKIAFQTSLGTPEFFDMSKRLRYEINE
DYKVRDELGPELFALWSKAPERWPPERLSKMYGLDFTLVRKILVWHHFKA
CYDACVEPDWSLPKRLFALEWIRDVRARKHGLFYGKMRFAEQKITFYSDR
FLFRDLVNRREASYANVWEMDDPYRFLQTEQDYEDYWGDNYDVYRRMFPE
MIGRTGEPVQQYGQMPIWAGPHRQHANKSEHNWMFAEIGVNVGHEALKKL
ELDPTNEKRRRFVIRQPDGTLRSAKMSEMRAWYWKEEWADFRFWAPQMEW
GIENTPSQEQYQEHVPDTTDADFRKQRRIQSRPVKWFYESHYTRTGSFAG
FQPLRFMQRRTEREVRWPDVINAAVQIQKRKPAAYIFKAIPE

3D structure

• PDB: 6hiy Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
• Chain: Ca
• Resolution: 3.27 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Ca	R10 Y11 P12 F13 P18 R19 A336 H339 K352 S357 R359 R363 R432 H523 G559 R568 R569 T570 E571 R572 E573 V574 R575 W576 P577 V579 N581 Q585 Q587 K588 R589 K590 Y594	R1 Y2 P3 F4 P9 R10 A327 H330 K343 S348 R350 R354 R423 H514 G550 R559 R560 T561 E562 R563 E564 V565 R566 W567 P568 V570 N572 Q576 Q578 K579 R580 K581 Y585

Gene Ontology

Cellular Component

• GO:0005739 mitochondrion
• GO:0005763 mitochondrial small ribosomal subunit

External links

• PDB: RCSB:6hiy, PDBe:6hiy, PDBj:6hiy
• PDBsum: 6hiy
• PubMed: 30213880
• UniProt: Q38DR3