Structure of PDB 8oeq Chain CW

Receptor sequence

>8oeqCW (length=178) Species: 5476 (Candida albicans) [Search protein sequence]

PRAPRTYSKTYSVPKRPYESARLDAELKLAGEYGLKNKREIYRIGFQLSK
IRRAARDLLTRDEKDPKRLFEGNALIRRLVRIGVLSEDKMKLDYVLALKP
EDFLERRLQTQVFKLGLARSIHHARVLITQRHIAVGKQIVNIPSFTVRLD
SQKHIDFAHNSPYGGGRAGRVKRKNQGK

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CW	P2 R3 R6 T7 Y8 S9 K10 T11 Y12 V14 K16 R17 Y19 K37 N38 K39 R40 R44 K51 F71 E72 A75 R78 R79 R82 R120 S121 H124 R126 Q131 H133 N142 I143 S145 F146 T147 R149 S152 Y164 G170 R171 K173 K175 N176	P1 R2 R5 T6 Y7 S8 K9 T10 Y11 V13 K15 R16 Y18 K36 N37 K38 R39 R43 K50 F70 E71 A74 R77 R78 R81 R119 S120 H123 R125 Q130 H132 N141 I142 S144 F145 T146 R148 S151 Y163 G169 R170 K172 K174 N175
BS02	MG	CW	K37 N38	K36 N37

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	A0A8H6F1X2

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