Structure of PDB 8oeq Chain CV

Receptor sequence

>8oeqCV (length=203) Species: 5476 (Candida albicans) [Search protein sequence]

GISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGPKRIHSVRTRGG
NQKFRALRVETGNFSWGSEGVSRKTRIAGVVYHPSNNELVRTNTLTKSAV
VQIDATPFRQWYENHYGATLGKKKGGAHAAHAAEVADAKRSRKVERKLAA
RSGAAAIESAVDSQFGSGRLYAVISSRPGQSGRCDGYILEGEELAFYLRR
LTA

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CV	E89 R92 D105 H129 S168 R170	E88 R91 D104 H128 S167 R169
BS02	rna	CV	G2 I3 R5 R8 H9 K10 R11 A13 T14 G15 A16 K17 A19 F21 R22 K23 K24 R25 K26 F27 L29 R31 Q32 P33 A34 R42 I43 R47 T48 R49 G50 G51 N52 K54 R56 L58 N64 S66 V72 S73 K75 S86 N87 K98 S99 N115 K140 S142 R143 K144 V145 R147 K148 R152 S176 R178 G180 Q181 S182 R184 D186 G187	G1 I2 R4 R7 H8 K9 R10 A12 T13 G14 A15 K16 A18 F20 R21 K22 K23 R24 K25 F26 L28 R30 Q31 P32 A33 R41 I42 R46 T47 R48 G49 G50 N51 K53 R55 L57 N63 S65 V71 S72 K74 S85 N86 K97 S98 N114 K139 S141 R142 K143 V144 R146 K147 R151 S175 R177 G179 Q180 S181 R183 D185 G186

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	A0A8H6F0S0

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