Structure of PDB 4v8z Chain CV

Receptor sequence

>4v8zCV (length=568) Species: 187420,559292

KDLRSPICCILGHVDTGKTKLLDKIRQTNVQGGEAGGITQQIGATYFPID
AIKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILV
IDIMHGLEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSF
AKQSRAVQEEFQSRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAV
TGEGVPDLLWLLLELTQKRMSKQLMYLSHVEATILEVKVVEGFGTTIDVI
LSNGYLREGDRIVLCGMNGPIVTNIRALLTPQPLRELRLKSEYVHHKEVK
AALGVKIAANDLEKAVSGSRLLVVGPEDDEDELMDDVMDAGVVVKADTLG
SLEAVVKILRDMYVPIKVADIGDVSRRDVVNAGIALQEDRVYGAIIAFNV
KVIPSAAQELKNSDIKLFQGNVIYRLMEEYEEWVRGIEEEKKKKWMEAII
KPASIRLIPKLVFRQSKPAIGGVEVLTGVIRQGYPLMNDDGETVGTVESM
QDKGENLKSASRGQKVAMAIKDAVYGKTIHEGDTLYVDIPENHYHILLTD
EELDLMDKIAEIKRKKNP

3D structure

• PDB: 4v8z Molecular architecture of a eukaryotic translational initiation complex.
• Chain: CV
• Resolution: 6.6 Å

Enzymatic activity

• Enzyme Commision number:
  3.6.5.3: protein-synthesizing GTPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CV	E241 G242 F243 G244 N274 R276 A277 E286 L287 R288 L289 K290 D384 V385 S386 R387 R388 D389 V390 V391 N392	E241 G242 F243 G244 N274 R276 A277 E286 L287 R288 L289 K290 D373 V374 S375 R376 R377 D378 V379 V380 N381
BS02	rna	CV	V14 D15 E81 F83 Q109 R134 V433 I434 Y435 R436 R475 Q476 S477 K478 P479 A480 I481 Q525 K526	V14 D15 E81 F83 Q109 R134 V422 I423 Y424 R425 R464 Q465 S466 K467 P468 A469 I470 Q514 K515
BS03	rna	CV	V535 Y536 G537 K538 T539 I540 H541	V524 Y525 G526 K527 T528 I529 H530

Gene Ontology

Molecular Function

• GO:0003743 translation initiation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006413 translational initiation

External links

• PDB: RCSB:4v8z, PDBe:4v8z, PDBj:4v8z
• PDBsum: 4v8z
• PubMed: 24200810
• UniProt: O26359|IF2P_METTH Probable translation initiation factor IF-2 (Gene Name=infB);
  P39730|IF2P_YEAST Eukaryotic translation initiation factor 5B (Gene Name=FUN12)