Structure of PDB 4v6x Chain CT

Receptor sequence

>4v6xCT (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEFMA

3D structure

PDB

4v6x Structures of the human and Drosophila 80S ribosome.

Chain

Resolution

5.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CT	T2 N3 K5 G6 R8 R9 R12 Y13 M14 R17 F19 H22 G23 K35 D41 T47 Q49 K50 H54 K55 H58 T61 Q69 H70 K81 K83 K87 K100 S101 S104 F105 R108 K116 K129 R130 F140	T1 N2 K4 G5 R7 R8 R11 Y12 M13 R16 F18 H21 G22 K34 D40 T46 Q48 K49 H53 K54 H57 T60 Q68 H69 K80 K82 K86 K99 S100 S103 F104 R107 K115 K128 R129 F139
BS02	rna	CT	R20 P26 L27 A28	R19 P25 L26 A27

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4v6x, PDBe:4v6x, PDBj:4v6x
PDBsum	4v6x
PubMed	23636399
UniProt	P46778\|RL21_HUMAN Large ribosomal subunit protein eL21 (Gene Name=RPL21)

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