Structure of PDB 5on6 Chain CS

Receptor sequence

>5on6CS (length=185) Species: 559292 (Saccharomyces cerevisiae S288C)

GIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKA
LFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTV
AALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVR
HFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV

3D structure

• PDB: 5on6 The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.
• Chain: CS
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CS	G2 H5 K8 Q9 H10 K11 R12 S13 G14 H15 R16 K20 S21 F35 R38 R39 P43 F44 L54 S55 K56 I57 S65 R66 R69 Q73 K79 T88 D89 D90 R92 I93 T107 Q135 N136 T137 I139 R141 P143 R144 N145 S146 R147 E148 R151 F153 P157 A162 P163 R164 S167 K171 F172 R174 R176 R179 R180 S181 K182 G183 F184 K185	G1 H4 K7 Q8 H9 K10 R11 S12 G13 H14 R15 K19 S20 F34 R37 R38 P42 F43 L53 S54 K55 I56 S64 R65 R68 Q72 K78 T87 D88 D89 R91 I92 T106 Q134 N135 T136 I138 R140 P142 R143 N144 S145 R146 E147 R150 F152 P156 A161 P162 R163 S166 K170 F171 R173 R175 R178 R179 S180 K181 G182 F183 K184

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5on6, PDBe:5on6, PDBj:5on6
• PDBsum: 5on6
• PubMed: 29429877
• UniProt: P0CX49|RL18A_YEAST Large ribosomal subunit protein eL18A (Gene Name=RPL18A)