Structure of PDB 8oeq Chain CR

Receptor sequence

>8oeqCR (length=260) Species: 5476 (Candida albicans) [Search protein sequence]

ARGPKKHLKRLAAPSHWMLDKLSGTYAPRPSAGPHKLRESLPLVVFLRNR
LKYALNGREVKAIMMQQHVQVDGKVRTDTTYPAGFMDVITLEATNEHFRL
VYDVKGKFAVHRISAEEAAYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPD
PLIRANDTVKIDLATGKIDDFIKFDTGRLVMVTGGRNLGRVGVIVHREKH
EGGFDLVHIKDALENTFVTRLSNVFVIGTEAGKPWVSLPKGKGIKLSISE
ERDRRRAQQG

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CR	A2 R3 G4 P5 K6 K7 H8 K10 R11 L12 M19 D21 K22 T26 Y27 A28 P29 R30 A33 G34 K37 L38 R49 N57 G58 R59 A63 M66 K75 R77 Y82 K106 L131 G132 K133 K134 G135 Y138 V140 T146 R148 R155 G186 R187 H201 E202 G203 V219 R221	A1 R2 G3 P4 K5 K6 H7 K9 R10 L11 M18 D20 K21 T25 Y26 A27 P28 R29 A32 G33 K36 L37 R48 N56 G57 R58 A62 M65 K74 R76 Y81 K105 L130 G131 K132 K133 G134 Y137 V139 T145 R147 R154 G185 R186 H200 E201 G202 V218 R220

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	A0A1D8PCI6\|RS4_CANAL Small ribosomal subunit protein eS4 (Gene Name=RPS42)

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