Structure of PDB 4v6x Chain CR

Receptor sequence

>4v6xCR (length=189) Species: 9606 (Homo sapiens)

MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLI
IRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMR
ILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKA
RKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLS

3D structure

• PDB: 4v6x Structures of the human and Drosophila 80S ribosome.
• Chain: CR
• Resolution: 5.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CR	R163 R170 R172 R173	R163 R170 R172 R173
BS02	rna	CR	M1 S2 M3 R5 L6 K8 R16 K20 K21 W23 L24 R38 Q39 R42 K43 K46 H58 S59 R60 R62 R64 R71 R74 H75 G77 I78 G79 K80 R81 K82 G83 T84 A87 R88 K92 V93 W95 M96 R103 R104 R107 R108 R110 K114 R117 H118 Y120 H121 Y124 L125 K128 G129 N130 N134 H143	M1 S2 M3 R5 L6 K8 R16 K20 K21 W23 L24 R38 Q39 R42 K43 K46 H58 S59 R60 R62 R64 R71 R74 H75 G77 I78 G79 K80 R81 K82 G83 T84 A87 R88 K92 V93 W95 M96 R103 R104 R107 R108 R110 K114 R117 H118 Y120 H121 Y124 L125 K128 G129 N130 N134 H143

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6x, PDBe:4v6x, PDBj:4v6x
• PDBsum: 4v6x
• PubMed: 23636399
• UniProt: P84098|RL19_HUMAN Large ribosomal subunit protein eL19 (Gene Name=RPL19)