Structure of PDB 8cq7 Chain CQ

Receptor sequence

>8cq7CQ (length=223) Species: 5476 (Candida albicans) [Search protein sequence]

AILSKKKKLVADGVFYAELNEFFTRELAEQGYAGVEVRKTPSKLEVIVKA
SNTQGVLGEQGRRIHELTSLIVKRFKLSPEGIAIYAERVEERGLSAAVQA
EALKAKLLSGLPIRRAAYGVLRFAMGAGAKGVEVVISGKLRAARAKSQKY
ADGFMIHSGQPTRDFIDIAIRHVLMRQGVLGIKVKIMKDPAANRFGPRAL
PDAVKIAEAKDEDEVIPAPTVKS

3D structure

PDB

8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CQ	I5 L6 S7 K8 K9 K10 R28 S140 K142 R144 A146 R147 A148 K152 F157 M158 I159 H160 S161 G162 Q163 H175 L177 R179 Q180 G181 V182 G184 K186 P204 D205	I2 L3 S4 K5 K6 K7 R25 S137 K139 R141 A143 R144 A145 K149 F154 M155 I156 H157 S158 G159 Q160 H172 L174 R176 Q177 G178 V179 G181 K183 P201 D202
BS02	MG	CQ	R117 Q151	R114 Q148

External links

PDB	RCSB:8cq7, PDBe:8cq7, PDBj:8cq7
PDBsum	8cq7
PubMed
UniProt	A0A8H6BYS1

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