Structure of PDB 6rxx Chain CI

Receptor sequence

>6rxxCI (length=822) Species: 209285 (Thermochaetoides thermophila)

ARQAARSHDIKEKRLHVPLVDRLPDEPPPRLVVIVGPPGVGKTTLLKSLV
RRYTKETMSDPVGPITVVTSKKQRLTFIECPNELEAMIDMAKVADIVLLM
IDGNYGFEMETMEFLNILANTGMPGNVFGILTHLDLFKKPSALKDAKKRL
KHRLWTELYQGAHLFYLSGVLNGRYPDREIHNLSRFLSVMKNPRPLVWRN
THPYTIIDNYRDITHPTKIEEDPLCDRTIELSGYLRGTNFAAQGQRVHIA
GVGDFTISKIEELPDPCPTPAMEKAPRRRLDEKDKKLWAPMADRSGMKIS
GDHIVITREKGFTFDKDANVERGEGEQLIVDLQGEKKLLGQTDKGVKLFA
GGEQLTQKPWRAIDLARLMYDTTLTPAQALRRWRGDYEELKTKWSNPENI
DALRRTRFQWYEMQKAMLQKQLDINKAEYAELDEHQRRQVEGYRAGKYAR
LVIEGVPAEFCKNFQPRMPILVGGLSATEDRFGFVQVRIKRHRWHKKILK
TGDPLIFSLGWRRFQTLPIYSIWDNRTRNRMLKYTPEHMHCFGTFWGPLI
APNTSFCCFQSFSASNPGFRIAATGTVLSVDESTEIVKKLKLVGTPWKIF
KNTAFIKDMFNSSLEIAKFEGAAIRTVSGIRGQIKRALSKPEGYFRATFE
DKILLSDIVILKAWYPVKPKQFYNPATNLIGWQSMRLTGEIRRAENIPTP
QNPNSTYRKIERPERHFNPLRVPKNLAAELPFKSQIVQTKPQKKETYMQK
RAVVVGREERKLRDLMQKLTTIRKEKIAKRKAKKEAQREKLKKELAEIEE
RRREKQKKEKKEFWEREGKKRK

3D structure

• PDB: 6rxx Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Chain: CI
• Resolution: 7.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CI	D48 K52 R53 V56 P57 L58 R325 E865 H866 M867 K929 E978 D979 P1028 S1033 P1041 E1042 R1043 H1044 N1046 P1047 L1048 R1049 V1050 K1052 A1056 W1142 E1143 G1146 K1147	D9 K13 R14 V17 P18 L19 R278 E537 H538 M539 K601 E650 D651 P700 S705 P713 E714 R715 H716 N718 P719 L720 R721 V722 K724 A728 W814 E815 G818 K819

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0034511 U3 snoRNA binding

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0030686 90S preribosome

External links

• PDB: RCSB:6rxx, PDBe:6rxx, PDBj:6rxx
• PDBsum: 6rxx
• PubMed: 31378463
• UniProt: G0S445