Structure of PDB 6xu6 Chain CG

Receptor sequence

>6xu6CG (length=241) Species: 7227 (Drosophila melanogaster)

KVVNQLFEKRPKNFGIGQNVQPKRDLSRFVRWPKYIRVQRQKAVLQKRLK
VPPPIHQFSQTLDKTTAVKLFKLLEKYRPESPLAKKLRLKKIAEAKAKGK
DVEPKKKPSYVSAGTNTVTKLIEQKKAQLVVIAHDVDPLELVLFLPALCR
KMGVPYCIVKGKARLGRLVRRKTCTTLALTTVDNNDKANFGKVLEAVKTN
FNERHEEIRRHWGGGILGSKSLARISKLERAKARELAQKQG

3D structure

• PDB: 6xu6 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
• Chain: CG
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CG	Y65 I66 Q69 R70 K94 H164 D165	Y35 I36 Q39 R40 K64 H134 D135
BS02	rna	CG	E38 K39 R40 P41 K42 G45 I46 N49 Q51 K53 R54 L56 R58 F59 R61 P63 K64 Y65 L75 R78 K80 E110 P112 K115 R118 Y140 A143 G144 T145 N146 T147 K150 Q154 D167 L171 K192 A193 R197 R201 K202 C204 T205 G248 S249 K250 S251 R254 K257	E8 K9 R10 P11 K12 G15 I16 N19 Q21 K23 R24 L26 R28 F29 R31 P33 K34 Y35 L45 R48 K50 E80 P82 K85 R88 Y110 A113 G114 T115 N116 T117 K120 Q124 D137 L141 K162 A163 R167 R171 K172 C174 T175 G218 S219 K220 S221 R224 K227

Gene Ontology

Biological Process

• GO:0042254 ribosome biogenesis

Cellular Component

• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xu6, PDBe:6xu6, PDBj:6xu6
• PDBsum: 6xu6
• PubMed: 34283226
• UniProt: P46223|RL7A_DROME Large ribosomal subunit protein eL8 (Gene Name=RpL7A)