Structure of PDB 4u24 Chain CE

Receptor sequence

>4u24CE (length=150) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

ELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAA
IQKAMEKARRNMINVALNNGTLQHPVKGVHTGSRVFMQPASEGTGIIAGG
AMRAVLEVAGVHNVLAKAYGSTNPINVVRATIDGLENMNSPEMVAAKRGK

3D structure

PDB

4u24 Synergy of streptogramin antibiotics occurs independently of their effects on translation.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CE	V21 S22 K23 T24 V25 K26 G27 R29 Y50 K52 K62 H89 T90 G91 F95 Q97 S100 I106 A107 G108 R112 L124 K126 A127 Y128 S130 T131 N132 N135 R138	V12 S13 K14 T15 V16 K17 G18 R20 Y41 K43 K53 H80 T81 G82 F86 Q88 S91 I97 A98 G99 R103 L115 K117 A118 Y119 S121 T122 N123 N126 R129

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0046677	response to antibiotic
GO:1990145	maintenance of translational fidelity

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4u24, PDBe:4u24, PDBj:4u24
PDBsum	4u24
PubMed	24957822
UniProt	P0A7W1\|RS5_ECOLI Small ribosomal subunit protein uS5 (Gene Name=rpsE)

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