Structure of PDB 6zmo Chain CD

Receptor sequence
>6zmoCD (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
KTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSF
KYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMIT
GTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNK
MDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEP
SANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVY
KIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALP
GDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQIS
AGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDM
VPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKK
3D structure
PDB6zmo Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
ChainCD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna CD R37 K41 K255 G258 R33 K37 K251 G254
BS02 rna CD K100 Y254 I259 V262 E293 H296 G309 H349 G351 Y357 A358 A369 K371 K408 M429 R430 K96 Y250 I255 V258 E289 H292 G305 H345 G347 Y353 A354 A365 K367 K404 M425 R426
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0044829 positive regulation by host of viral genome replication
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904714 regulation of chaperone-mediated autophagy
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0030864 cortical actin cytoskeleton
GO:0032587 ruffle membrane
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:0098574 cytoplasmic side of lysosomal membrane
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zmo, PDBe:6zmo, PDBj:6zmo
PDBsum6zmo
PubMed32680882
UniProtP68104|EF1A1_HUMAN Elongation factor 1-alpha 1 (Gene Name=EEF1A1)

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