Structure of PDB 4v6x Chain CD

Receptor sequence

>4v6xCD (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]

NKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNR
DIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARR
LLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNK
VFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYM
RYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPK
KEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES

3D structure

PDB

4v6x Structures of the human and Drosophila 80S ribosome.

Chain

Resolution

5.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	CD	Y12 R15 Y16 Q17 K19 R23 T28 R35 K43 Y44 T46 K48 F113 G140 A141 T143 Y145 A148 L150 T153 F160 P174 S176 K178 R179 R268 D278 Q282 R289	Y4 R7 Y8 Q9 K11 R15 T20 R27 K35 Y36 T38 K40 F105 G132 A133 T135 Y137 A140 L142 T145 F152 P166 S168 K170 R171 R260 D270 Q274 R281
BS02	rna	CD	K10 F13 K14 Y16 V18 R21 R22 R24 T28 Y30 R33 I52 R54 T56 N57 I61 Q63 I69 E70 G71 D72 M73 I74 G91 N94 R152 T154 T155 N157 K158 P181 Y207 F223 Q225 Y253 K258 K259 E260 K262 K263 W266 K270 L273 K276 R279 V280	K2 F5 K6 Y8 V10 R13 R14 R16 T20 Y22 R25 I44 R46 T48 N49 I53 Q55 I61 E62 G63 D64 M65 I66 G83 N86 R144 T146 T147 N149 K150 P173 Y199 F215 Q217 Y245 K250 K251 E252 K254 K255 W258 K262 L265 K268 R271 V272

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0048027	mRNA 5'-UTR binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0010628	positive regulation of gene expression
GO:0042273	ribosomal large subunit biogenesis
GO:0045727	positive regulation of translation
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4v6x, PDBe:4v6x, PDBj:4v6x
PDBsum	4v6x
PubMed	23636399
UniProt	P46777\|RL5_HUMAN Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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