Structure of PDB 7pbc Chain CCC

Receptor sequence

>7pbcCCC (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]

SHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPW
IEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGC
DVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAH
VAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATL
RCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPS
GQEQRYTCHVQHEGLPKPLTLRWEP

3D structure

PDB

7pbc Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.

Chain

CCC

Resolution

2.04 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	CCC	Y8 E64 K67 V68 H71 T74 V77 D78 Y85 Y100 Y117 T144 K147 W148 V153 L157 Y160 W168 Y172	Y6 E62 K65 V66 H69 T72 V75 D76 Y83 Y98 Y115 T142 K145 W146 V151 L155 Y158 W166 Y170

External links

PDB	RCSB:7pbc, PDBe:7pbc, PDBj:7pbc
PDBsum	7pbc
PubMed	35851311
UniProt	Q861F7

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