Structure of PDB 6tq1 Chain CCC

Receptor sequence

>6tq1CCC (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]

TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT
IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQ
KVASMPQ

3D structure

PDB

6tq1 Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

Chain

CCC

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NUH	CCC	W97 P98 Q101 V103 L108 N156 I162	W22 P23 Q26 V28 L33 N81 I87

External links

PDB	RCSB:6tq1, PDBe:6tq1, PDBj:6tq1
PDBsum	6tq1
PubMed	31904959
UniProt	P25440\|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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