Structure of PDB 6t8u Chain CCC

Receptor sequence
>6t8uCCC (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
SLCGMVWEGTDYHKQPWQAKISVIHESCMGAVVSEYFVLTAAHCFSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQ
TIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKL
TRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYA
DPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCVPAHARDFHINLFQV
LPWLKEKLQDEDLGFL
3D structure
PDB6t8u Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
ChainCCC
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MVZ CCC E97I Y99 P172D C191 R192 S195 W215 G216 V218 D218A E81 Y83 P174 C205 R206 S209 W229 G230 V232 D233
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t8u, PDBe:6t8u, PDBj:6t8u
PDBsum6t8u
PubMed32073845
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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