Structure of PDB 6rlw Chain CCC

Receptor sequence

>6rlwCCC (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]

MGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLA
DQVWTLTQTEEQLHCTVYRKSQASRPTPDELEAVRKYFQLDVTLAQLYHH
WGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERL
CQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASA
RAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKP
QAVPVDVHMWHIAQRDYSWHPSPQTNKELGNFFRSLWGPYAGWAQAVLFS
ADL

3D structure

PDB

6rlw Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.

Chain

CCC

Resolution

2.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	K249 D268
Catalytic site (residue number reindexed from 1)	K237 D256
Enzyme Commision number	3.2.2.- 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K8Q	CCC	G42 K249 M257 H270 Q315 A316 F319	G32 K237 M245 H258 Q295 A296 F299

Gene Ontology

	Molecular Function
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016829	lyase activity
GO:0019104	DNA N-glycosylase activity
GO:0019899	enzyme binding
GO:0032357	oxidized purine DNA binding
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0140097	catalytic activity, acting on DNA

	Biological Process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of DNA-templated transcription
GO:0006974	DNA damage response
GO:0006979	response to oxidative stress
GO:0009314	response to radiation
GO:0009410	response to xenobiotic stimulus
GO:0009416	response to light stimulus
GO:0032355	response to estradiol
GO:0034614	cellular response to reactive oxygen species
GO:0043066	negative regulation of apoptotic process
GO:0044029	positive regulation of gene expression via chromosomal CpG island demethylation
GO:0045007	depurination
GO:0045008	depyrimidination
GO:0045471	response to ethanol
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0051593	response to folic acid
GO:0071276	cellular response to cadmium ion
GO:1901291	negative regulation of double-strand break repair via single-strand annealing

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0032991	protein-containing complex

View graph for
Molecular Function

View graph for
Biological Process

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Cellular Component

External links

PDB	RCSB:6rlw, PDBe:6rlw, PDBj:6rlw
PDBsum	6rlw
PubMed	33211885
UniProt	O15527\|OGG1_HUMAN N-glycosylase/DNA lyase (Gene Name=OGG1)

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