Structure of PDB 6qsw Chain CCC

Receptor sequence
>6qswCCC (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLCGMVWDYHKQPWQAKISVIGHESCMGAVVSEYFVLTAAHCFSIKVSV
GGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQT
IRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYAD
PNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCAHARDFHINLFQVLPW
LKEKLQDEDLGFL
3D structure
PDB6qsw Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
ChainCCC
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JGT CCC Y99 P172D Y172F R192 S214 W215 G216 V217 V218 Y82 P173 Y175 R205 S227 W228 G229 V230 V231 BindingDB: IC50=6600nM,Kd=10000nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qsw, PDBe:6qsw, PDBj:6qsw
PDBsum6qsw
PubMed30926668
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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