Structure of PDB 8y0x Chain CB

Receptor sequence
>8y0xCB (length=755) Species: 9606 (Homo sapiens) [Search protein sequence]
NFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAG
ETRFTDTTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEV
TAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALL
ELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFG
SGLHGWAFTLKQFAEMYVAKFAERAKKVEDMMKKLWGDRYFDPANGKFSK
SATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDS
EDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEG
PPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGL
KVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGV
DQFLVKTGTITTFEHAHNMRDPVVSYRETVSEESNVLCLSKSPNKHNRLY
MKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFG
PDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFD
VHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPE
QVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSN
TGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDN
FLDKL
3D structure
PDB8y0x The global structure of dormant ribosome
ChainCB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna CB H27 V137 R162 P596 N597 K598 E753 Y760 R765 R801 S802 G805 H25 V122 R147 P493 N494 K495 E650 Y657 R662 R698 S699 G702
BS02 rna CB R633 K667 I714 G717 G719 Q720 R530 K564 I611 G614 G616 Q617
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0045296 cadherin binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006412 translation
GO:0006414 translational elongation
GO:0045727 positive regulation of translation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0034774 secretory granule lumen
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y0x, PDBe:8y0x, PDBj:8y0x
PDBsum8y0x
PubMed38698775
UniProtP13639|EF2_HUMAN Elongation factor 2 (Gene Name=EEF2)

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