Structure of PDB 8y0w Chain CB

Receptor sequence
>8y0wCB (length=768) Species: 9606 (Homo sapiens) [Search protein sequence]
NFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAG
ETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINL
IDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIK
PVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGN
IMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAERAKKVEDMMKKLWG
DRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEET
AKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPV
TAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYA
FGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIE
DVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRDPVVSYRETVSEESNVL
CLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYE
WDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEG
ALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRL
MEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPV
NESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRK
RKGLKEGIPALDNFLDKL
3D structure
PDB8y0w dormant ribosome with eIF5A, eEF2 and SERBP1
ChainCB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna CB H27 R66 V137 R162 E753 Y760 R765 V770 R801 S802 G805 H25 R64 V135 R160 E663 Y670 R675 V680 R711 S712 G715
BS02 rna CB K407 K629 R633 Q670 N673 H715 K395 K539 R543 Q580 N583 H625
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0045296 cadherin binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006412 translation
GO:0006414 translational elongation
GO:0045727 positive regulation of translation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0034774 secretory granule lumen
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y0w, PDBe:8y0w, PDBj:8y0w
PDBsum8y0w
PubMed38698775
UniProtP13639|EF2_HUMAN Elongation factor 2 (Gene Name=EEF2)

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