Structure of PDB 6z6n Chain CB

Receptor sequence
>6z6nCB (length=846) Species: 9606 (Homo sapiens) [Search protein sequence]
NFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAG
ETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINL
IDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIK
PVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGN
IMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAERAKKVEDMMKKLWG
DRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEET
AKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPV
TAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYA
FGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIE
DVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAK
NPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLE
EDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDG
LAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNIL
TDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHAD
AIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGV
LNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQC
VFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
3D structure
PDB6z6n Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
ChainCB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna CB H27 H108 V137 R162 P723 R726 Y760 N764 R765 V770 R801 S802 G805 K845 N853 H25 H106 V135 R160 P711 R714 Y748 N752 R753 V758 R789 S790 G793 K833 N841
BS02 rna CB K667 G668 Q670 I714 G717 G718 G719 Q720 K655 G656 Q658 I702 G705 G706 G707 Q708
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0045296 cadherin binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006412 translation
GO:0006414 translational elongation
GO:0045727 positive regulation of translation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0034774 secretory granule lumen
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6z6n, PDBe:6z6n, PDBj:6z6n
PDBsum6z6n
PubMed32687489
UniProtP13639|EF2_HUMAN Elongation factor 2 (Gene Name=EEF2)

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