Structure of PDB 9ey8 Chain CA

Receptor sequence
>9ey8CA (length=447) Species: 9606 (Homo sapiens) [Search protein sequence]
QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRP
HSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQ
RVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDG
NTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWH
RYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDS
TLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMV
QRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVR
SLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADIST
FPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSR
3D structure
PDB9ey8 Interactions of phenylalanine derivatives with human tyrosinase: lessons from experimental and theoretical studies.
ChainCA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.18.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TY2 CA H215 R374 H381 L382 G389 T391 S394 H191 R350 H357 L358 G365 T367 S370
BS02 ZN CA H192 H215 H224 H168 H191 H200
BS03 ZN CA H377 H381 H404 H353 H357 H380
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:9ey8, PDBe:9ey8, PDBj:9ey8
PDBsum9ey8
PubMed38642076
UniProtP17643|TYRP1_HUMAN 5,6-dihydroxyindole-2-carboxylic acid oxidase (Gene Name=TYRP1)

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