Structure of PDB 7zrs Chain CA

Receptor sequence
>7zrsCA (length=1742) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KYEAGSTTAMAFAGQKFTLPVGTTRMSYNTHEEIIIPAADQASNKNYLYT
KLLKISDLDHFCKTVFPYETLNQIQSLVYPVAYKTNENMLICAPTGAGKT
DIALLTIINTIKQFIDIQYDDFKVIYVAPLKALAAEIVDKFSKKLAPFNI
QVRELTGDMQLTKAEILATQVIVTTPEKWDVVTRKANGDNDLVSKVKLLI
IDEVHLLHEDRGSVIETLVARTLRQVESSQSMIRIIGLSATLPNFMDVAD
FLGVNRQIGMFYFDQSFRPKPLEQQLLGCRGKAGSRQSKENIDKVAYDKL
SEMIQRGYQVMVFVHSRKETVKSARNFIKLAESNHEVDLFAPDPIEKDKY
SRSLVKNRDKDMKEIFQFGFGIHHAGMARSDRNLTEKMFKDGAIKVLCCT
ATLAWGVNLPADCVIIKGTQVYDSKKGGFIDLGISDVIQIFGRGGRPGFG
SANGTGILCTSNDRLDHYVSLITQQHPIESRFGSKLVDNLNAEISLGSVT
NVDEAIEWLGYTYMFVRMRKNPFTYGIDWEEIANDPQLYERRRKMIVVAA
RRLHALQMIVFDEVSMHFIAKDLGRVSSDFYLLNESVEIFNQMCDPRATE
ADVLSMISMSSEFDGIKFREEESKELKRLSDESVECQIGSQLDTPQGKAN
VLLQAYISQTRIFDSALSSDSNYVAQNSVRICRALFLIGVNRRWGKFSNV
MLNICKSIEKRLWAFDHPLCQFDLPENIIRRIRDTKPSMEHLLELEADEL
GELVHNKKAGSRLYKILSRFPKINIEAEIFPITTNVMRIHIALGPDFVWD
SRIHGDAQFFWVFVEESDKSQILHFEKFILNRRQLNNQHEMDFMIPLSDP
LPPQVVVKVVSDTWIGCESTHAISFQHLIRPFNETLQTKLLKLRPLPTSA
LQNPLIESIYPFKYFNPMQTMTFYTLYNTNENAFVGSPTGSGKTIVAELA
IWHAFKTFPGKKIVYIAPMKALVRERVDDWRKKITPVTGDKVVELTGDSL
PDPKDVHDATIVITTPEKFDGISRNWQTRKFVQDVSLIIMDEIHLLASDR
GPILEMIVSRMNYISSQTKQPVRLLGMSTAVSNAYDMAGWLGVKDHGLYN
FPSSVRPVPLKMYIDGFPDNLAFCPLMKTMNKPVFMAIKQHSPDKPALIF
VASRRQTRLTALDLIHLCGMEDNPRRFLNIDDEEELQYYLSQVTDDTLKL
SLQFGIGLHHAGLVQKDRSISHQLFQKNKIQILIATSTLAWGVNLPAHLV
IIKGTQFFDAKIEGYRDMDLTDILQMMGRAGRPAYDTTGTAIVYTKESKK
MFYKHFLNVGFPVESSLHKVLDDHLGAEITSGSITNKQEALDFLSWTFLF
RRAHHNPTYYGIEDDTSTAGVSEHLSSLIDSTLENLRESQCVLLHGDDIV
ATPFLSISSYYYISHLTIRQLLKQIHDHATFQEVLRWLSLAVEYNELPVR
GGEIIMNEEMSQQSRYSVESTFTDEFELPMWDPHVKTFLLLQAHLSRVDL
PIADYIQDTVSVLDQSLRILQAYIDVASELGYFHTVLTMIKMMQCIKQGY
WYEDDPVSVLPGLQLRRIKDYTFSEQGFIEMTPQQKKKKLLTLEEIGRFG
YKKLLNVFDQLTFGMTESEDTKKRFVSVCQRLPVLEGMKFEEQENNEVLT
FYSKHLSSKHNNGFEVYCDKFPKIQKELWFLIGHKGDELLMIKRCQPKQM
NKEVIIHCDLFIPEEIRGEELQFSLINDALGLRYDMVHKLIS
3D structure
PDB7zrs Structural basis for clearing of ribosome collisions by the RQT complex.
ChainCA
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna CA R577 V580 K581 R583 R604 S605 K612 H980 K982 R1027 D1031 R352 V355 K356 R358 R379 S380 K387 H755 K757 R802 D806
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006417 regulation of translation
GO:0032790 ribosome disassembly
GO:0051607 defense response to virus
GO:0072344 rescue of stalled ribosome
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zrs, PDBe:7zrs, PDBj:7zrs
PDBsum7zrs
PubMed36801861
UniProtP53327|SLH1_YEAST RQC trigger complex helicase SLH1 (Gene Name=SLH1)

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