Structure of PDB 6zmi Chain CA

Receptor sequence
>6zmiCA (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
QQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMI
MEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLV
KIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRL
VKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPT
DQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYG
LKMKTSRAFFSEVERRFDAMPFTLRAFEKKARMGVVECAKHELLQPFNVL
YEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALL
QSSA
3D structure
PDB6zmi Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
ChainCA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D109 N120 H188 D196 D227 K320
Catalytic site (residue number reindexed from 1) D103 N114 H182 D190 D221 K312
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna CA K211 Q254 Y255 G256 L257 K258 K260 R263 F266 S267 K205 Q248 Y249 G250 L251 K252 K254 R257 F260 S261
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0043066 negative regulation of apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zmi, PDBe:6zmi, PDBj:6zmi
PDBsum6zmi
PubMed32680882
UniProtQ9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 (Gene Name=PA2G4)

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