Structure of PDB 8xxn Chain C1

Receptor sequence
>8xxnC1 (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
PAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTV
IEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF
3D structure
PDB8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
ChainC1
Resolution3.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C1 K64 A68 C69 N70 K41 A45 C46 N47
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, RNA binding
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:1905746 positive regulation of mRNA cis splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum8xxn
PubMed38641729
UniProtP41567|EIF1_HUMAN Eukaryotic translation initiation factor 1 (Gene Name=EIF1)

[Back to BioLiP]