Structure of PDB 8gym Chain C1

Receptor sequence

>8gymC1 (length=674) Species: 312017 (Tetrahymena thermophila SB210)

VSVNNYFYYLDRIKKLFTYLNDLRKHILKKYVYTINHKRIAINYLYFSMV
TGLSGAALATMIRLELAHPGSPFFKGDSLRYLQVVTAHGLIMVFFVVVPI
LFGGFANFLIPYHVGSKDVAYPRLNSIGFWIQPCGYILLAKIGFLRPQFW
RYYDKTSFSFPFLEKMKYNQYKEYKNDYLFYLDFLKKEITDDHSFFWKAR
KVIKLPQYSVFSFVPLKLMMWKTMINYPESFWYAASRVVQSRRKKVFVTK
CSARTLTTAGWTFITPFSSNIKYTGVGSQDILILSVVFAGISTTISFTNL
LITRRTLAMPGLRHRRVLMPFVTISIFLTLRMLATITPVLGAAVIMMAFD
RHWQTTFFEYAYGGDPILSQHLFWFFGHPEVYVLIIPTFGFINMIVPHNN
TRRVASKHHMIWAIYVMAYMGYLVWGHHMYLVGLDHRSRTMYSTITIMIS
MPATIKVVNWTLSLVNGALKIDLPFLFSMSFLLLFLVAGFTGMWLSHVSL
NVSMHDTFYVVAHFHIMLSGAAMTGIFSGIYYYFNALFGVKYSRMFGYMH
LIYYSGGQWVAFVPLFYLGFSGMPRRIHDYPVVFMGWHSMSTTGHFITLV
GIIFFFLMMFDSHIERRASTSTTLGLPRWYKRISYYIFKIRYLQHTKSKM
NGIPGSTVRLMLINRHFVEYEVYE

3D structure

• PDB: 8gym Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
• Chain: C1
• Resolution: 2.96 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEA	C1	M62 G65 I75 R76 Y94 V98 H101 M105 I113 W274 F521 F527 H528 L531 S532 M536 F540 I543 F575 R588 R589 H608 I615	M49 G52 I62 R63 Y81 V85 H88 M92 I100 W261 F508 F514 H515 L518 S519 M523 F527 I530 F562 R575 R576 H595 I602
BS02	HEA	C1	W274 W387 V394 I398 H440 H441 A466 G502 F503 G505 M506 L508 S509 N514 H518 V523 H526 F527 M530 L531 R588	W261 W374 V381 I385 H427 H428 A453 G489 F490 G492 M493 L495 S496 N501 H505 V510 H513 F514 M517 L518 R575
BS03	CU	C1	H391 H440 H441	H378 H427 H428
BS04	MG	C1	H518 D519	H505 D506

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8gym, PDBe:8gym, PDBj:8gym
• PDBsum: 8gym
• PubMed: 37248254
• UniProt: Q950Y4