Structure of PDB 9bp9 Chain C

Receptor sequence
>9bp9C (length=741) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPT
SAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIK
VDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE
LHMLGDSHRGYLLELLLTKICYITRKSASSNAVQIVGMSATLPNLELVAS
WLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVEDHVVSL
CYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEQKELLEVMDQ
LRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAAT
STLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESI
LICKNSEKSKGIALLQGSLKPVRSCLVTGSMIRAILEIIVGGVASTSQDM
HTYAACTFLAASMGAIEACVMWLLENEFIQSTEKVYHPTHLGSATLSSSL
SPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLW
EKLPTSMKRVAELVGVEEGFLARCVKGKQHRQMAIHKRFFTSLVLLDLIS
EVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVE
VILKNAVPMRTIWVTGRKGLTEREAAALIVEEARMILQQDL
3D structure
PDB9bp9 Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
ChainC
Resolution3.21 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WCN C F181 E192 R193 G196 L197 R200 K206 S621 S622 V757 M761 Q782 F114 E125 R126 G129 L130 R133 K139 S498 S499 V627 M631 Q652
External links
PDB RCSB:9bp9, PDBe:9bp9, PDBj:9bp9
PDBsum9bp9
PubMed39143110
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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