Structure of PDB 9box Chain C

Receptor sequence

>9boxC (length=453) Species: 9606 (Homo sapiens) [Search protein sequence]

WTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCL
NNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYS
GSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFES
MPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCD
EVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFY
RKGVKAPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYS
LQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLE
LVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEG
VNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGF
DEH

3D structure

PDB

9box Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function.

Chain

Resolution

2.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	A1AQW	C	Y96 Y106 G325	Y54 Y64 G274
BS02	FFO	C	E98 Y105 Y106 F317	E56 Y63 Y64 F266
BS03	A1AQW	C	S76 S142 G143 S144 H171 T225 S226 D251 A253 H254 H279 K280 R425	S34 S100 G101 S102 H129 T183 S184 D209 A211 H212 H237 K238 R374
BS04	FFO	C	L166 G169 G170 H171 I183 S226 N410 S417 A418 I419	L124 G127 G128 H129 I141 S184 N359 S366 A367 I368

External links

PDB	RCSB:9box, PDBe:9box, PDBj:9box
PDBsum	9box
PubMed	39148791
UniProt	P34897\|GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial (Gene Name=SHMT2)

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