Structure of PDB 9b6g Chain C

Receptor sequence
>9b6gC (length=915) Species: 10090 (Mus musculus) [Search protein sequence]
DLVNFIQANFDAFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLVI
SVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVV
RDNTISENIVAIGIAAWGMVSNRDTLFSAQYIMILDNNHTHLLLVAKLRN
QLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVV
EGSGQIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEIL
ESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLE
WNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQ
KFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRTR
HPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDI
NAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLE
LAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCG
LVSFRKLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTP
ELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRL
HSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDV
FFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPS
DVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLST
NILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVV
FAYFYMVVKKNETLAWEGVMKENYLVKINTKANDNSEEMRHRFRQLDSKL
NDLKSLLKEIANNIK
3D structure
PDB9b6g Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
ChainC
Resolution2.81 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 C I962 S966 L971 I795 S799 L804
BS02 Y01 C W954 I957 W787 I790
BS03 Y01 C W798 L841 I857 W631 L674 I690
BS04 Y01 C L750 F847 S850 L853 L583 F680 S683 L686
BS05 Y01 C F735 S739 V743 V849 F568 S572 V576 V682
BS06 LQ7 C N741 L778 E782 D802 F839 R842 Y1005 R1008 F1013 N574 L611 E615 D635 F672 R675 Y838 R841 F846
External links
PDB RCSB:9b6g, PDBe:9b6g, PDBj:9b6g
PDBsum9b6g
PubMed39093967
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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