Structure of PDB 9azx Chain C

Receptor sequence
>9azxC (length=166) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
NSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGAL
NKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKG
EDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYL
AVFDKNLYDKLVSSFL
3D structure
PDB9azx GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.
ChainC
Resolution1.395 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AH3 C D22 I23 A38 N40 G46 G48 V49 A50 L126 S128 A129 G130 I131 F132 F156 D19 I20 A35 N37 G43 G45 V46 A47 L123 S125 A126 G127 I128 F129 F153
External links
PDB RCSB:9azx, PDBe:9azx, PDBj:9azx
PDBsum9azx
PubMed38646883
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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