Structure of PDB 9axh Chain C

Receptor sequence
>9axhC (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDNQDHLKLFKKEVMNYRQTR
HENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQ
EIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVNQLKLS
HDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLK
NQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSL
LMDMLEKLP
3D structure
PDB9axh The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
ChainC
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP C A637 R639 C689 F740 A24 R26 C74 F125
BS02 MG C N738 D750 N123 D135
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:9axh, PDBe:9axh, PDBj:9axh
PDBsum9axh
PubMed38588399
UniProtQ8IVT5|KSR1_HUMAN Kinase suppressor of Ras 1 (Gene Name=KSR1)

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