Structure of PDB 8zyp Chain C

Receptor sequence

>8zypC (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]

KAVWDWLILLLVIYTAVFTPYSAAFLLKLAVVDLIVDIMFIVDILINFGR
IAVHYFKGWFLIDMVAAIPFDLLIGLLKTARLLRLVRVARKLDRYSEYGA
AVLFLLMCTFALIAHWLACIWYAIGNMEQPHRIGWLHNLGDQIGKPYGGP
SIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASI
FGNVSAIIQR

3D structure

PDB

8zyp Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors

Chain

Resolution

3.19 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1L2J	C	S621 L622 S624 M645 G648 S649 Y652	S166 L167 S169 M190 G193 S194 Y197

External links

PDB	RCSB:8zyp, PDBe:8zyp, PDBj:8zyp
PDBsum	8zyp
PubMed
UniProt	Q12809\|KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (Gene Name=KCNH2)

[Back to BioLiP]