Structure of PDB 8zr5 Chain C

Receptor sequence
>8zr5C (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
SFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIG
VAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYL
AIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQC
SFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHA
GAMAGDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYL
WLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVK
3D structure
PDB8zr5 Cryo-EM structure of GPR119-Gs complex
ChainC
Resolution3.31 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1D8M C A90 L94 S156 F157 L169 F174 W238 F241 R262 W265 A85 L89 S151 F152 L164 F169 W224 F227 R248 W251
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0031210 phosphatidylcholine binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0019222 regulation of metabolic process
GO:0030073 insulin secretion
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043235 receptor complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8zr5, PDBe:8zr5, PDBj:8zr5
PDBsum8zr5
PubMed
UniProtQ8TDV5|GP119_HUMAN Glucose-dependent insulinotropic receptor (Gene Name=GPR119)

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