Structure of PDB 8yte Chain C

Receptor sequence
>8yteC (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
SFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEF
LEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMD
3D structure
PDB8yte Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.
ChainC
Resolution2.26 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C P311 S312 L313 E324 S326 F329 T330 F332 P335 P29 S30 L31 E42 S44 F47 T48 F50 P53
BS02 GM1 C L313 R314 L31 R32
External links
PDB RCSB:8yte, PDBe:8yte, PDBj:8yte
PDBsum8yte
PubMed38950284
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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