Structure of PDB 8yp3 Chain C

Receptor sequence

>8yp3C (length=467) Species: 7108 (Spodoptera frugiperda) [Search protein sequence]

HHHHMSYDSIFENLNSHGQGHLLKYWPDLSEKERAQLLNDLKKIDFAEVN
ELFRRANDLKPIPDSHYEAVPNLSNEKILEYENIGLREISDGKVGVLLLA
GGQATRLGFGHPKGMYDVGLPSRKTLFQIQAERIVRVQQMAAEKYGKEGK
ITWYIMTSEHTRGPTADYFRSHNYFGLNEEDIVYFEQGTLPCFDFEGKIF
LDEKYHVSSAPDGNGGLYRALKNQGVLDDIAKRGVEHLHAHSVDNILIKV
ADPVFIGYCKSKNADCAAKVVQKSTPSEAVGVVCRVNGHYKVVEYSELTD
EAAESRTADGRLTFSAGNICNHYFSSEFLTKICNFESKLKLHVAKKKIPY
VDHEGVRQKPTEPNGIKMEKFIFDVFEFAENFICLEVARDVEFSALKNND
AAKKDCPSTAREDLLRLHRKYVREAGGIVEDNIDVEISPLLSYGGENLTD
LVSGEVFTISPYHLKSM

3D structure

PDB

8yp3 Structure and Inhibition of Insect UDP- N -acetylglucosamine Pyrophosphorylase: A Key Enzyme in the Hexosamine Biosynthesis Pathway.

Chain

Resolution

2.12 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UD1	C	L113 G115 G116 Q201 G227 N228 S256 V257 V294 G295 E308 Y309 N332 F387 K411	L99 G101 G102 Q187 G213 N214 S242 V243 V280 G281 E294 Y295 N318 F373 K397
BS02	MG	C	N332 C334 H336	N318 C320 H322

External links

PDB	RCSB:8yp3, PDBe:8yp3, PDBj:8yp3
PDBsum	8yp3
PubMed	39039661
UniProt	A0A2H1VI03

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