Structure of PDB 8yhw Chain C

Receptor sequence
>8yhwC (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
EEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLT
EKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRL
EVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKE
QGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALC
DFGHAVCLQPDGLGYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHML
NGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIH
RVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP
3D structure
PDB8yhw The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus
ChainC
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS C G407 G409 F411 G412 V414 K429 M469 L472 D519 L522 D534 G74 G76 F78 G79 V81 K96 M136 L139 D186 L189 D201
BS02 MG C N520 D534 N187 D201
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8yhw, PDBe:8yhw, PDBj:8yhw
PDBsum8yhw
PubMed
UniProtQ99558|M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (Gene Name=MAP3K14)

[Back to BioLiP]