Structure of PDB 8x54 Chain C

Receptor sequence
>8x54C (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
GAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASV
VWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGL
ASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHG
DSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTS
GLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLL
3D structure
PDB8x54 Molecular mechanism of substrate recognition and cleavage by human gamma-secretase
ChainC
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR C Y69 I73 L198 L206 Y68 I72 L197 L205
BS02 CLR C L199 S223 W227 L198 S222 W226
BS03 CLR C L214 Y218 L213 Y217
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030674 protein-macromolecule adaptor activity
GO:0061133 endopeptidase activator activity
Biological Process
GO:0001656 metanephros development
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0010950 positive regulation of endopeptidase activity
GO:0016485 protein processing
GO:0031293 membrane protein intracellular domain proteolysis
GO:0034205 amyloid-beta formation
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0042734 presynaptic membrane
GO:0070765 gamma-secretase complex
GO:0097060 synaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8x54, PDBe:8x54, PDBj:8x54
PDBsum8x54
PubMed38843321
UniProtQ96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A (Gene Name=APH1A)

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