Structure of PDB 8x1z Chain C

Receptor sequence

>8x1zC (length=553) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL
KQKKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLP
MGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRET
KLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQ
YALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVS

3D structure

PDB

8x1z Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.

Chain

Resolution

2.62 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	W24 F61 L74 R78 E89 Q91 I94 G152 P157 Y183 M184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 T473 Q475 Y501	W24 F61 L74 R78 E89 Q91 I94 G152 P157 Y183 M184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 T473 Q475 Y501
BS02	MG	C	D110 V111 D185	D110 V111 D185
BS03	XTE	C	K65 R72 D110 V111 A114 F115 M184 D185	K65 R72 D110 V111 A114 F115 M184 D185

External links

PDB	RCSB:8x1z, PDBe:8x1z, PDBj:8x1z
PDBsum	8x1z
PubMed	38977798
UniProt	P12497\|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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