Structure of PDB 8wy7 Chain C

Receptor sequence

>8wy7C (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]

RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDM
GTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLF
LQKINELPT

3D structure

PDB

8wy7 Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.

Chain

Resolution

2.83 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XHN	C	F83 L94 N140 I146	F26 L37 N83 I89

External links

PDB	RCSB:8wy7, PDBe:8wy7, PDBj:8wy7
PDBsum	8wy7
PubMed	38175809
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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