Structure of PDB 8wpk Chain C

Receptor sequence
>8wpkC (length=218) Species: 10244 (Monkeypox virus) [Search protein sequence]
MNSVTISHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFF
IQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLT
GVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITK
HVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDHQFEKDRSFEIINV
LLELDNKTPINWAQGFIY
3D structure
PDB8wpk Structural insights into the assembly and mechanism of monkeypox virus DNA polymerase complex F8-A22-E4-H5
ChainC
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna C K160 T161 Y180 H181 A184 R185 K160 T161 Y180 H181 A184 R185
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:8wpk, PDBe:8wpk, PDBj:8wpk
PDBsum8wpk
PubMed37995690
UniProtM1LL92|UNG_MONPV Uracil-DNA glycosylase (Gene Name=OPG116)

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