Structure of PDB 8wpf Chain C

Receptor sequence
>8wpfC (length=218) Species: 10244 (Monkeypox virus) [Search protein sequence]
MNSVTISHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFF
IQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLT
GVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITK
HVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDHQFEKDRSFEIINV
LLELDNKTPINWAQGFIY
3D structure
PDB8wpf Structural insights into the assembly and mechanism of monkeypox virus DNA polymerase complex F8-A22-E4-H5
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C D68 Y70 K87 S88 T130 K160 T161 Y180 H181 A184 R185 Q188 D68 Y70 K87 S88 T130 K160 T161 Y180 H181 A184 R185 Q188
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8wpf, PDBe:8wpf, PDBj:8wpf
PDBsum8wpf
PubMed37995690
UniProtM1LL92|UNG_MONPV Uracil-DNA glycosylase (Gene Name=OPG116)

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